2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N7079AR
    Sodium erythorbate (Standard) 6381-77-7 98%
    Sodium erythorbate (Standard) (D-Isoascorbic acid (sodium) (Standard)) is the analytical standard of Sodium erythorbate (HY-N7079A). This product is intended for research and analytical applications. Sodium erythorbate is an orally active sodium salt form of isoascorbic acid. Sodium erythorbate improves the radiation resistance of Listeria monocytogenes. Sodium erythorbate can react with free radicals and reduce oxidative damage. Sodium erythorbate has weak antiscorbic activity. Sodium erythorbate can prevent oxidative discoloration in meat products.
    Sodium erythorbate (Standard)
  • HY-N7091S1
    Atrazine-13C3,15N3 2117346-98-0 98%
    Atrazine-13C3,15N3 is the 13C-labeled and 15N-labeled Atrazine. Atrazine is principally used for control of certain annual broadleaf and grass weeds. Atrazine inhibits photophosphorylation but typically does not result in lethality or permanent cell damage in the short term.
    Atrazine-13C3,15N3
  • HY-N8016S1
    Nonanal-d4 1335401-96-1 98%
    Nonanal-d4 is deuterated labeled Nonanal (HY-N8016). Nonanal is a saturated fatty aldehyde with antidiarrhoeal activity.
    Nonanal-d4
  • HY-N8016S2
    Nonanal-d2 1335435-50-1 98%
    Nonanal-d2 is deuterated labeled Nonanal (HY-N8016). Nonanal is a saturated fatty aldehyde with antidiarrhoeal activity.
    Nonanal-d2
  • HY-N9516AR
    Taurodehydrocholic acid sodium (Standard) 57011-24-2 98%
    Taurodehydrocholic acid (sodium) (Standard) is the analytical standard of Taurodehydrocholic acid (sodium) (HY-N9516A). This product is intended for research and analytical applications. Taurodehydrocholic acid sodium is a biliary cholesterol secretion activator. Taurodehydrocholic acid sodium significantly increases the expression of Abcg5 and decreases the expression of abc8. Taurodehydrocholic acid sodium can be used in the study of cholesterol metabolism.
    Taurodehydrocholic acid sodium (Standard)
  • HY-P0014AS
    Liraglutide-d8 tetraTFA 98%
    Liraglutide-d8 tetraTFA is deuterium labeled Liraglutide (HY-P0014). Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used for the study of type 2 diabetes mellitus.
    Liraglutide-d8 tetraTFA
  • HY-P990138
    Anti-Monkey/Human CD20 Antibody (2H7) 98%
    Anti-Monkey/Human CD20 Antibody (2H7) is a mouse-derived IgG2b κ type antibody inhibitor, targeting to monkey/human CD20. Anti-Monkey/Human CD20 Antibody (2H7) specifically depletes B cells. Anti-Monkey/Human CD20 Antibody (2H7) can be used for the researches of inflammation and metabolic disease, such as diabetes and experimental autoimmune encephalomyelitis.
    Anti-Monkey/Human CD20 Antibody (2H7)
  • HY-P990152
    Anti-Mouse TIM-4 Antibody (RMT4-54) 98%
    Anti-Mouse TIM-4 Antibody (RMT4-54) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse TIM-4. Anti-Mouse TIM-4 Antibody (RMT4-54) reacts with mouse T cell immunoglobulin and mucin domain 4 (TIM-4) and blocks TIM-4 signaling. Anti-Mouse TIM-4 Antibody (RMT4-54) inhibits phagocytosis of apoptotic cells. Anti-Mouse TIM-4 Antibody (RMT4-54) can be used for the researches of immunology and metabolic disease.
    Anti-Mouse TIM-4 Antibody (RMT4-54)
  • HY-P990197
    Anti-Mouse MAdCAM-1 Antibody (MECA-367)
    Anti-Mouse MAdCAM-1 Antibody (MECA-367) is an anti-mouse MAdCAM-1 IgG2a monoclonal antibody. Anti-Mouse MAdCAM-1 Antibody (MECA-367) significantly inhibits the migration of pig peripheral blood lymphocytes (PBL) by blocking the function of MAdCAM-1. Anti-Mouse MAdCAM-1 Antibody (MECA-367) selectively inhibits B cell migration to exacerbate inflammation. Anti-Mouse MAdCAM-1 Antibody (MECA-367) can be used for researches on inflammation, metabolic conditions and xenotransplantation such as colitis and diabetes.
    Anti-Mouse MAdCAM-1 Antibody (MECA-367)
  • HY-P990252
    Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) 98%
    Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) is an anti-mouse Delta-like protein 4/DLL4 IgG monoclonal antibody. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can reduce angiogenesis and density by blocking the DLL4-Notch signaling pathway. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) reduces inflammatory response by decreasing NF-κB activity and pro-inflammatory factors (IL-1β, iNOS, IL-6) levels. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can inhibit Th17 cell differentiation and IL-17A production. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can reduce macrophage infiltration and alleviate insulin resistance. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can be used for researches on inflammation, metabolic conditions and cancer such as atherosclerosis, pancreatic cancer and asthma.
    Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2)
  • HY-P990823
    Anti-Mouse PD-L1/B7-H1 Antibody (10F.2H11) 98%
    Anti-Mouse PD-L1/B7-H1 Antibody (10F.2H11) is rat-derived IgG2b κ type antibody inhibitor, targeting to PD-L1/B7-H1. Anti-Mouse PD-L1/B7-H1 Antibody (10F.2H11) can block PD-L1/ B7-1 interactions and does not block PD-L1/PD-1 interactions. Anti-Mouse PD-L1/B7-H1 Antibody (10F.2H11) can be used for the researches of cancer, infection, immunology and metabolic disease, such as MB49 tumor, heart graft and diabetes.
    Anti-Mouse PD-L1/B7-H1 Antibody (10F.2H11)
  • HY-P990846
    Anti-Fy3 Antibody (MIMA-29) 98%
    Anti-Fy3 Antibody (MIMA-29) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human Fy3. Anti-Fy3 Antibody (MIMA-29) binds to erythrocytes and induces RBC (red blood cells) clearance. Anti-Fy3 Antibody (MIMA-29) can be used for the research of metabolic disease .
    Anti-Fy3 Antibody (MIMA-29)
  • HY-P991221
    ALD1613 98%
    ALD1613 is a potent neutralizing monoclonal antibody against adrenocorticotropic hormone (ACTH). ALD1613 neutralizes ACTH-induced signaling and inhibits ACTH-induced cyclic AMP accumulation in a mouse adrenal cell line (Y1) via all five melanocortin receptors. ALD1613 significantly reduces plasma corticosterone levels in wild-type rats. ALD1613 can be used in the study of diseases associated with elevated ACTH levels.
    ALD1613
  • HY-RS16302
    PKD2 Pig Pre-designed siRNA Set A 98%

    PKD2 Pig Pre-designed siRNA Set A contains three designed siRNAs for PKD2 gene (Pig), as well as a negative control, a positive control, and a FAM-labeled negative control.
    PKD2 Pig Pre-designed siRNA Set A
  • HY-RS29458
    Tmem19 Mouse Pre-designed siRNA Set A 98%
    Tmem19 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tmem19 (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Components
    Tmem19 siRNA-1: 5 nmol (HPLC)
    Tmem19 siRNA-2: 5 nmol (HPLC)
    Tmem19 siRNA-3: 5 nmol (HPLC)
    siRNA Negative Control: 5 nmol (HPLC)
    FAM-labeled siRNA Negative Control: 5 nmol (HPLC)
    GAPDH siRNA Positive Control: 5 nmol (HPLC)
    Tmem19 Mouse Pre-designed siRNA Set A
  • HY-RS29459
    Tmem19 Rat Pre-designed siRNA Set A 98%
    Tmem19 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tmem19 (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Components
    Tmem19 siRNA-1: 5 nmol (HPLC)
    Tmem19 siRNA-2: 5 nmol (HPLC)
    Tmem19 siRNA-3: 5 nmol (HPLC)
    siRNA Negative Control: 5 nmol (HPLC)
    FAM-labeled siRNA Negative Control: 5 nmol (HPLC)
    GAPDH siRNA Positive Control: 5 nmol (HPLC)
    Tmem19 Rat Pre-designed siRNA Set A
  • HY-RS29460
    SREBF1 Pig Pre-designed siRNA Set A 98%
    SREBF1 Pig Pre-designed siRNA Set A contains three designed siRNAs for SREBF1 (Pig), as well as a negative control, a positive control, and a FAM-labeled negative control.
    SREBF1 Pig Pre-designed siRNA Set A
  • HY-RS29486
    SLC25A15 Mouse Pre-designed siRNA Set A
    SLC25A15 Mouse Pre-designed siRNA Set A contains three designed siRNAs for SLC25A15 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Components
    SLC25A15 siRNA-1: 5 nmol (HPLC)
    SLC25A15 siRNA-2: 5 nmol (HPLC)
    SLC25A15 siRNA-3: 5 nmol (HPLC)
    siRNA Negative Control: 5 nmol (HPLC)
    FAM-labeled siRNA Negative Control: 5 nmol (HPLC)
    GAPDH siRNA Positive Control: 5 nmol (HPLC)
    SLC25A15 Mouse Pre-designed siRNA Set A
  • HY-RS29495
    Glis3 Mouse Pre-designed siRNA Set A
    Glis3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Glis3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Components
    Glis3 siRNA-1: 5 nmol (HPLC)
    Glis3 siRNA-2: 5 nmol (HPLC)
    Glis3 siRNA-3: 5 nmol (HPLC)
    siRNA Negative Control: 5 nmol (HPLC)
    FAM-labeled siRNA Negative Control: 5 nmol (HPLC)
    GAPDH siRNA Positive Control: 5 nmol (HPLC)
    Glis3 Mouse Pre-designed siRNA Set A
  • HY-RS29505
    Dnajc15 Mouse Pre-designed siRNA Set A 98%
    Dnajc15 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dnajc15 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Components
    Dnajc15 siRNA-1: 5 nmol (HPLC)
    Dnajc15 siRNA-2: 5 nmol (HPLC)
    Dnajc15 siRNA-3: 5 nmol (HPLC)
    siRNA Negative Control: 5 nmol (HPLC)
    FAM-labeled siRNA Negative Control: 5 nmol (HPLC)
    GAPDH siRNA Positive Control: 5 nmol (HPLC)
    Dnajc15 Mouse Pre-designed siRNA Set A
Cat. No. Product Name / Synonyms Application Reactivity